![](/__local/9/55/7A/B42A732DC19A58B326D781FE620_BDE591E7_7C44.jpg)
2007年于英国爱丁堡大学获得博士学位。2007-2019年先后在西班牙巴塞罗那CRG、美国费城Wistar Institute、迈阿密大学癌症中心从事转录和转录后调控的分子机制研究。2020年作为suncitygroup太阳集团杰出人才引进,加入suncitygroup太阳集团生命科学中心任研究员。
生信专业招收方向
1.各种高通量测序结果的生信分析方法
2.应用生物信息学手段研究寡聚核苷酸药物作用的分子机制
代表性文章
1.Lai F, Damle S, Ling KK, Rigo F. Directed RNase H cleavage of nascent transcripts causes transcription termination. Molecular Cell (2020),77(5): 1032-1043
2.Yue J#, Lai F#, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Genes & Development (2017), 31(17): 1809-1820
3.Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F*, Shiekhattar R*, Chen JF*. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Science Advances (2016) 2:2(9): e1601167
4.Lai F, Gardini A, Zhang A, Shiekhattar R. Integrator mediates the biogenesis of enhancer RNAs. Nature (2015) 525: 399-403;
5.Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shiekhattar R. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature (2013), 494: 497-501
6.Lai F, Thacker J, Li Y, and Doerner P. Cell division activity determines the magnitude of phosphate starvation responses in Arabidopsis. Plant J. 2007, 50(3) 545-556 (Cover)
7.Lai F, Blumenthal E, Shiekhattar R. Detection and Analysis of Long Noncoding RNAs. Methods in Enzymology. 2016 Mar. 28th.
8.Lai F, Shiekhattar R. Enhancer RNAs: the new molecules of transcription. Curr Opin Genet & Dev. 2014 Apr, 25: 38-42;